SlashDotDash
Legacy Member
DekadeZ zei:De discussie was, imho, mateloos interessant. En eerlijk gezegd is het zoeken naar ervaringsdeskundigen mbt. geneesmiddelen op een gamesfora nu niet meteen the way to go. Zoek dan beter een site waar (ouders van) mensen met AD(H)D hun Rilatine-gebruik bespreken.
Volledig akkoord.
Om toch nog even on topic te reageren; ik heb snel even gezocht en een recente meta-analyse gevonden van een aantal studies rond het gebruik van psychostimulantia (waaronder methylphenidaat) bij depressie.
Plain language summary
Psychostimulants for depression
Depression is common and under-treated. The current first-line drug treatment for moderate or severe depression is antidepressants, but there are problems with their use. This review evaluated the evidence from randomised controlled trials (RCTs) evaluating the effectiveness of psychostimulants (PS) in the treatment of depression. Twenty-four RCTs were identified, of which 14 had data for meta-analysis. Five drugs were evaluated, including dexamphetamine, methylphenidate, methylamphetamine, pemoline and modafinil. Modafinil was evaluated separately as its pharmacology differs from other PS. Three small trials of PS involving a total of 62 participants indicated that oral treatment with PS in the short term (up to four weeks) significantly reduced depressive symptoms when compared with placebo, however, the overall quality of the trials was poor, limiting confidence in the findings. Two trials involving 411 participants compared modafinil against placebo when combined with antidepressant treatment at 6-8 weeks, and showed a non-significant difference in reducing depression symptoms. One small trial of 50 participants compared oral modafinil against placebo after 12 weeks of treatment, and also showed a non-significant difference in reducing depression symptoms. No trials examined the longer-term effect of PS. Further well conducted trials with long term follow-up are required to find out which PS may be more effective in the treatment of depression, and whether PS are more effective in certain subgroups of depressed patients.
En
Authors' conclusions
There is some evidence that in the short-term, PS reduce symptoms of depression. Whilst this reduction is statistically significant, the clinical significance is less clear. Larger high quality trials with longer follow-up and evaluation of tolerance and dependence are needed to test the robustness of these findings and, furthermore, to explore which PS may be more beneficial and in which clinical situations they are optimal.
Bron: Psychostimulants for depression, M Candy B; Jones L; Williams R; Tookman A; King, Cochrane Database of Systematic Reviews 2008 Issue 2.
Tbegon me 1tje per dag, savonds. Da hebbek 2 jaar volgehoude.. Op den duur snuifde'k er zo'n 6-10 per dag. Gelukkig da niemand iets gemerkt heeft.. Nu nemek gewoon ne concerta van 54mg, oraal welliswaar, en kdenk dak blij mag zijn dak nog gezond ben. achja. Voor die die het willen snuiven: Uwe neus ga naar de reet & na veel ervaring bemerk ik dat oraal een sterker effect heeft. -_- En nog een ervaring: Roken gaat niet samen met rilatine, na een (lange) tijd zal de werking van rilatine afnemen omdat nicotine de dopamine-receptoren bezet, en rilatine dus geen plaats meer heeft.